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doi: 10.1016/j.eprac.2022.04.009

Conclusion AOD-9604 and semaglutide are not competing alternatives that each offer different trade-offs they represent fundamentally different places on the spectrum between scientific hypothesis and clinical proof

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The MASH/liver Phase 3 studies On the liver side, the program includes a Phase 3 trial in non-cirrhotic MASH with F2F3 fibrosis (LIVERAGE, NCT06632444) and a study in participants with compensated MASH cirrhosis (LIVERAGE-Cirrhosis, NCT06632457), the latter evaluating liver-related clinical outcomes over a multi-year horizon

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As many as 73 percent of subjects experienced nausea, 47 percent vomiting, and 25 percent diarrhea